Prophylaxis and reversal of ifosfamide encephalopathy with methylene-blue. Kupfer A, Aeschlimann C, Wermuth B, Cerny T. Laparoscopic microsurgical tubal anastomosis. Methemoglobinemia induced by methylene blue perturbation during laparoscopy. Methylene blue as a cause of chemical peritonitis in a patient on peritoneal dialysis. Macia M, Gallego E, Garcia-Cobaleda I, et al. Radiculomyelopathy following intrathecal instillation of methylene blue. Ocular complications of a topical methylene blue-vasoconstrictor-anesthetic preparation. Solutions can be hazardous for lacrimal system irrigation. 2013 Annual report of the American association of poison control centers’ national poison data system (NPDS): 31st annual report. Mowry JB, Spyker DA, Cantilena Jr LR, et al. The pharmacological basis of therapeutics. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. It is likely that these data represented a fraction of its total antidotal use. Its use has been increasing methylene blue was reported to be administered 105 and 85 times in the USA in 19, respectively. Methylene blue was reported to have been administered as an antidote in the USA 149 times in 2013 (116 in patients over 20 years old) by US poison centers. A major use of methylene blue by clinical toxicologists is in the treatment of methemoglobinemia, a condition discussed in detail in the Hematologic Syndromes chapter. They may vary between countries.) Methylene blue also has many nontoxicologic medical uses. (Trade names given here are examples from those used in the USA. Today, however, methylene blue continues to be a component of certain medications, used to treat urinary tract infections, including Atrosept, Dolsed, UAA, Uridon modified, Urised, Uritin, and Prosed/DS. Since that time, methylene blue has mostly been abandoned for these clinical indications owing to the discovery of much more effective agents. It was also used as an intestinal and urinary antiseptic since the nineteenth century. Methylene blue was one of the first antimalarial agents to be used clinically.
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